Dear Researcher,

        When you fill out the form,  related article will be sent to you automatically as PDF file.

        Thanks for your interest and cooperation.

Article # : SC02

Sema Çalış, Ph.D.

Professor

IN VITRO ADSORPTION OF  PROPRANOLOL  HYDROCHLORIDE  BY VARIOUS ANTACIDS

S.Çalış, M.Şumnu, A.A.Hıncal

Hacettepe  University,  Faculty  of  Pharmacy, Pharmaceutical Technology Department, 06100 Ankara-TURKEY

Summary

The purpose of this study was to investigate by in vitro .methods whether an interaction takes placec between propranolol hydrochloride and adsorbents when antacids are taken concomitantly with  the betabloker or when excipients having adsorbent properties are present in formulations of the drugproducts containing propranolol hydrcchloride.

Specific surface areas of magnesium trisilicate, magnesium oxide, magnesium hydroxide, dihydroxy aluminum sodium carbonate, magnesiumcarbonate and kaolin were calculated from nitrogen adsorption isoterms using single point method and it was found  that magnesium trisilicate has the largest specific surface area.

The absorption of propranolol hydrochloride to these adsorbents was investigated by in vitro methods. The adsorption isotherms were drawn and the adsorptive cacaclfcles of the adsorbents were calculated from the slopes. It was found that magnesium trisilicate, magnesium hydroxide and dihydrcxy aluminum sodium carbonate possess the highest adsorptive capacities while kaolin and magnesium carbonate possess the lowest.

The results of the adsorption studies indicate that the concomitant use of propranolol hydochloride and the above mentioned adsorbents could affect the bioavailability of the betablocker adversely.

Key  words

Adsorption, BET  adsorption isotherms, propranolol hydrochloride, specific surface area.