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Article # : SC03

Sema Çalış, Ph.D.

Professor

Formulation and In vitro — In vivo Evaluations on Sustained Release Acetylsalicylic Acid Tablets

Y. Çapan, S. Şenel, S. Çalış, S. Takka, and A. A. Hıncal

Department of Pharmaceutical Technology, Faculty of Pharmacy University of  Hacettepe, Ankara (Turkey)

Summary

The mode of administrating drugs in a sustained-release form has recently assumed considerable importance in the pharmaceutical industry. In the present paper the release of drug incorporated into polymethylmethacrylates (PMMA). Polivinyl chloride (PVC) and carbomer (CM) matrix were studied. The data obtained from in vitro tests showed that the formulation containing 15 % CM yield good sustained release matrix tablets. The sustained release properties of acetylsalicylic acid (ASA) in 15%   CM matrix were evaluated by conducting urinary excretion studies in 6 healthy subjects. The average maximum role of excretion after a unit dose of conventional ASA was used as a basis of comparison, for the sustained release dosage form. Bioavailabilily comparisons showed that the sustained release ASA tablet gave more uniform excretion rates than the conventional release tablets.