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Article # : SC06

Sema Çalış, Ph.D.

Professor

COLORIMETRIC  DETERMINATION  OF  A NOVEL ANTIMICROBIAL  SURFACTANT  MIXTURE  (C31G)

Sema ÇALIŞ(*), Ünsal ÇALIŞ(**), Murat ŞUMNU(*), A. Atilla HINCAL(*)
 

(*)Department of Pharmaceutical Technology, (**)Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University 06100    

    Ankara-Turkey

Summary

C31G is a potent broad spectrum antimicrobial surfactant mixture. Except for the microbiological procedures, scintillation of the radioactive form of this mixture is the only assay method reported. In this paper, a new, sensitive and a reproducible colonmetric assay method based on the formation of Reineckate complex in the acidic medium is presented. Obedience to Beer's law permitted the successful application of this proposed assay method for the performance of the content uniformity testing from the formulated vaginal suppositories.

Key words

Surfactant mixture, Alkyl betaines assay, C31G.