Dear Researcher, When you fill out the form, related article will be sent to you automatically as PDF file. Thanks for your interest and cooperation. |
|||
Article # : SC13 |
Sema Çalış, Ph.D. Professor |
||
Effect of suppository bases on the release properties of a potent antimicrobial agent (C31 G)
S. ÇALIŞ, M. ŞUMNU and A. A. HINCAL
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Summary C31G is a specific formulation which contains equal molar concentrations of alkyi N-betaine and alkyl N.N-dimethylamine oxide. Vaginal suppositories containing 500 mg of C31G, this potent antimicrobial substance, were prepared by the fusion method in a variety of Suppocire® and Witepsol® bases with different melting points and hydroxyl values. In vitro release and diffusion characteristics of C31G from different suppository bases were investigated using two different systems. The release from suppositories was determined by using a system without a membrane and the diffusion rate of the released agent was determined through a semipermeable dialyzing tubing. Diffusion kinetics from suppositories were evaluated in terms of the apparent dialytic rate constants using the equation developed by Davis et al. From the results of in vitro studies, Witepsol H 15 and Suppocire CM bases were selected as the most suitable ones for the formulations of C31G vaginal suppositories, since it is imperative for topical formulations to release the active substance in high proportions which are not absorbable by the mucosal membranes.
| |||
×× Back to Articles&Proceedings
|