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Article # : SC17

Sema Çalış, Ph.D.

Professor

Formulation and stability evaluation of enteric-coated omeprazole formulations

S. Bozdag, S. Çalis and M. Sumnu

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey

Summary

Omeprazole, a substituted benzimidazole, is a specific and noncompetitive inhibitor of the enzyme H⁺/K⁺-ATPase, known as the gastric proton pump. It is unstable in conditions of low pH and must be protected from the effects of gastric acid when given orally; thus, it is administered in the form of enteric coated dosage/arms. In this present study, various coating solutions were prepared in different concentrations andappliedto previously subcoated omeprazole tablets to examine whether this coating preventedomeprazolefrom degrading in acidic media. Dissolution tests were conducted in acidic and basic media to determine the appropriate coating ratio. For stability evaluation, an accelerated stability test was performed on developed tablet formulations and commercially obtained capsules. Samples were examined with regard to visual appearance, omeprazole content and dissolution propertiesfor a month. Forformulation consideration, the most promising results were obtained from HPMCP₄ and CAP₄ (4% enteric coating with hydroxypropylmethyl cellulose phthalate solution and cellulose acetate phthalate solution, respectively) subcoded preparations. From the stability aspect only Losec capsules (Astro-Turkey, commercial product) seem to be dependable.

Key words

Omeprazole, Tablets, Enteric coating, Stability.