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Article # : SC31

Sema Çalış, Ph.D.

Professor

5-Fluorouracil encapsulated alginate beads for the treatment of breast cancer

B. Arıca^a, S. Çalış^a,  H.S. Kaş^a, M.F. Sargon^b, A.A. Hıncal^a

^a Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhıye-Ankara, Turkey

^b Department of Anatomy, Faculty of Medicine, Hacettepe University, 06100  Sıhhıye-Ankara, Turkey

Summary

Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w.... v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5 FU was investigated. As the drug load increased, larger beads were obtained in which the resultant beads contained higher 5-FU content. The encapsulation efficiencies obtained for 5-FU loads of 1.0, 5.0 and 10% (w.... v) were 3.5, 7.4 and 10%, respectively. Scanning electron microscopy (SEM) and particle size analysis revealed differences between the formulations as to their appearance and size distribution. The amount of 5-FU released from the alginate beads increased with decreasing alginate concentrations.

Key words

5-Fluorouracil; Alginate beads; Biodegradable polymers; Breast cancer