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Article # : SC34

Sema Çalış, Ph.D.

Professor

5-Fluorouracil in topical liposome gels for anticancer

treatment – Formulation and evaluation

MARIJA GLAVAS-DODOV ^{1 *}, EMILIJA FREDRO-KUMBARADZI ¹, KATERINA GORACINOVA ¹, SEMA CALIS ², MAJA SIMONOSKA ¹, ATILA A. HINCAL ²

¹ Department of Pharmaceutical Technology, Faculty of Pharmacy, University 'Ss Cyril and  

  Methodious', 1000 Skopje, Macedonia

² Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara,

  Turkey

Summary

Liposome gels bearing an antineoplastic agent, 5-fluoro-uracil, intended for topical application have been prepared and drug release properties in vitro have been evaluated. Different formulations of liposomes were prepared by the film hydration method by varying the lipid phase com-position (PL 90H/cholesterol mass ratio) and hydration conditions of dry lipid film (drug/aqueous phase mass ratio). Topical liposome gels were prepared by incorpo-ration of lyophilized liposomes into a structured vehicle (1%, m/m, chitosan gel base). Also, hydrogels containing different concentrations of 5-fluorouracil were prepared and drug release properties were investigated. The rate of drug release from liposome gels was found to be de-pendent

on the bilayer composition and the dry lipid film hydration conditions. Also, liposomes embedded into a structured vehicle of chitosan showed significantly slow-er release than hydrogels. The drug release obeyed the Higuchi diffusion model, while liposomes acted as reser-voir systems for continuous delivery of the encapsulated drug.

Key words

 liposomes, 5-fluorouracil, chitosan gel, drug release