Publications

- Y. Çapan

   Formulation de Comprimés de Nitrofurantoin à   Libération Modifiée Obtenus par        

   Compression Directe

   Labo-Pharma-Probl. Tech., 31, 837 (1983)

 

- Y. Çapan

   Les Formes Pharmaceutiques Orales Solides  à Libération Programée.

   Sci. Techn. Pharm., 13, 43 (1984)

 

- Y. Çapan

   Influence of Technological Factors on Formulation of Sustained Release Tablets.

  Drug Dev. Ind. Pharm., 15, 927 (1989)

 

- Y. Çapan, S. Şenel, S. Çalış, S. Takka, A. A. Hıncal

   Formulation and In Vitro- In Vivo Evaluations on Sustained Release Acetylsalicylic       

   Acid Tablets.

   Pharm. Ind., 51, 443 (1989)

 

- F. Bulut-Öner, Y. Çapan, S. Kaş, L. Öner, A. A. Hıncal

  Sustained Release Isoniasid Tablets.

   I. Formulation and In Vitro Evaluation

   Farmaco., 44 ,739 (1989)

 

- K. Çiftçi, Y. Çapan, O. Öztürk, A. A. Hıncal

   Formulation and In Vitro- In Vivo Evaluation of   Sustained Release Lithium            

   Carbonate Tablets.

  Pharm. Res. , 7, 359 (1990)

 

- Y. Çapan, S. Kaş, L. Öner, F. Bulut-Öner, A. A. Hıncal

   Sustained Release Isoniasid Tablets  II. In Vivo Evaluation

   S.T.P. Pharma Sciences, 6, 460 (1990)

 

-Y. Çapan, K. Çiftçi, A.A. Hıncal

   Influence of Filler Excipients on the Release Rate  of Sustained Release Lithium        

   Carbonate Tablets.

   Eur. J. Pharm. Biopharm., 37, 14 (1991)

 

- K. Çiftçi, Y. Çapan, A. A. Hıncal

   Evaluation of Sustained Release Lithium Carbonate Tablets from Urine

   S.T.P. Pharma Sciences, 1, 272 (1991)

 

- S. Şenel, Y. Çapan, T. Dalkara, N. İnanç, A. A. Hıncal

   Formulation, Bioavailability and Pharmacokinetics of  Sustained Release Potassium   

   Chloride Tablets.

   Pharm. Res., 8, 1313 (1991)

 

- S. Şenel, Y. Çapan, A. A. Hıncal

   Factors Affecting the Formulation of Sustained Release Potassium Chloride Tablets

   Pharmazie, 46, 792 (1991)

 

- Y. Çapan, N. Çapan, H. S. Kaş, Ş. Atikcan, Y. Başer, A. A. Hıncal

   Formulation and Efficiency of Sustained Release Theophylline Tablets

  S.T.P. Pharma Sciences, 2, 169 (1992)

 

- Ş. Anlar, Y. Çapan, A. A. Hıncal

  Physico-Chemical and Bioadhesive Properties of  Polyacrylic Acid Polymers.

  Pharmazie, 48, 285 (1993)

 

- Ş. Anlar, Y. Çapan, O. Güven, A. Göğüş, T. Dalkara, A. A. Hıncal

  Formulation and In vitro- In vivo Evaluation of Buccoadhesive Morphine Sulphate

  Tablets.

  Pharm. Res., 11, 231 (1994)

 

- F.S. Farshi, Y. Çapan, S. Kas, A.A. Hıncal

  Formulation  and  Comparative  Bioavailability  of  Conventional  and  Sustained-        

  Release  Furosemide  Tablets.

  S.T.P. Pharma Sciences, 5, 361 (1995)

 

- B. Taylan, Y. Çapan, O. Güven, S. Kas, A. A. Hıncal

  Design and Evaluation of Sustained-Release and Buccoadhesive Propranolol   

  Hydrochloride Tablets.

  J. Control. Rel., 38, 11 (1996)

 

 -S. Şenel, Y. Çapan, M.F. Sargon, G. İkinci, D. Şolpan , O. Güven, H.E. Bodde,

  A.A.Hıncal    

  Enhancement  of  Transbuccal Permeation of Morphine Sulfate by Sodium 

  Glycodeoxycholate In Vitro.

  J. Control. Rel., 45, 153 (1997)

 

- S. Şenel, D. Duchêne, A.A. Hıncal, Y. Çapan, G. Ponchel 

  In Vitro Studies on Enhancing Effect of Sodium Glycocholate on Transbuccal  

  Permeation of Morphine Hydrochloride.

  J. Control. Rel., 51, 107 (1998)

 

- S. Şenel, Y. Çapan, M.F. Sargon, C.B. Giray, A.A. Hıncal

  Histological and Bioadhesion Studies on Buccal Bioadhesive Tablets Incorporated

  with a Penetration Enhancer, Sodium Glycodeoxycholate.

  Int. J. Pharm., 170, 239 (1998)

 

- Y. Yazıksız-İşcan, Y, Çapan, S. Şenel, M.F. Şahin, S. Kes, D. Duchêne, A. Atilla

  Hıncal.

  Formulation and In vitro In vivo Evaluation of Buccal Bioadhesive Captopril Tablets

  STP Pharma, 8, 357 (1998)

 

- G.İkinci, Y.Çapan, S.Şenel, T. Dalkara, A.A. Hıncal

  Formulation and In Vitro-In Vivo investigation of carbamazepine controlled release   

  matrix tablets

  Pharmazie, 54, 139 (1999)

 

-Y.Çapan, B.H. Woo, S. Gebrekidan, S.Ahmed, P.P.DeLuca.

  Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for  

  controlled release of plasmid DNA.

  Pharm. Res. 16, 509 (1999)

 

- Y.Çapan, B.H. Woo, S. Gebrekidan, S.Ahmed, P.P.DeLuca

  Influence of formulation parameters on the characteristics of poly(D,L- lactide-co-

  glycolide) microsphere containing poly(L-lysine)complexed plasmid DNA.

  J. Control. Rel. 60, 279 (1999)

 

- Y.Çapan, B.H. Woo, S. Gebrekidan, S.Ahmed, P.P.DeLuca

  Stability of poly(L-Lysine) complexed plasmid DNA.

  Pharm.Dev. Tech. 4, 491 (1999)

 

- G. İkinci, Y. Çapan, S. Şenel, E. Alaaddinoğlu, T. Dalkara, A. A. Hıncal

  In vitro/in vivo studies on buccal bioadhesive tablet formulation of carbamazepine

  Pharmazie,  55,762 (2000).

 

- Y. Çapan, G. Jiang, S. Giovagnoli, K. Na, P. P. DeLuca

  Preparation and characterization of poly(D,L- lactide-co-glycolide) microspheres

  for controlled release of human growth hormone 

  AAPS PhamSciTech,  4, 236 (2003).

 

- R. Elqidra, N. Ünlü, Y. Çapan, G. Şahin, T. Dalkara, A. A. Hıncal

  Effect of polymorphism on in vitro- in vivo properties of carbamazepine

  conventional tablets.

  J. Drug Del. Sci. Tech., 14,147,( 2004)

 

- S. Bozdağ, Y. Çapan, İ.Vural, T. Dalkara, A.L. Dogan, D. Guc, A. A. Hıncal,

  In vitro Cytotoxıcıty of Mitoxantron-Incorporated Albumin Microspheres on Acute

  Promyelocytic Leukemia Cells

  Journal of Microencapsulation, 21,751 (2004)

 

- S. Bozdağ, Y. Çapan, İ.Vural, T. Dalkara, A.L. Dogan, D. Guc, A. A. Hıncal, 

  P.P.DeLuca,

  Formulation and In Vitro Cytotoxicity of Mitoxantron- Loaded Biodegradable

  Microspheres on  Rat Glioma Cells

  J. Drug Del. Sci. Tech., 15, 201 ( 2005 )

 

- Y.Aktas, K.Andrieux, M.J.Alonso, P.Calvo, R.N.Gursoy, P.Couvreur, Y.Capan

  Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase

  inhibitor

  Int J Pharm. 298,378 (2005)

 

- A.C. Kilic, Y. Capan, I. Vural, R. N. Gursoy, T. Dalkara, A. Cuine, A. Hincal,

  Preparation and characterization of PLGA nanospheres for the targeted delivery of

  NR2B-spesific antisense oligonucleotides to the NMDA receptors in the brain

Journal of Microencapsulation 22,633 (2005)

 

- M. Cetin, Y.Capan, İ.Vural, L.A.Dogan, D.Guc, A.A.Hincal, P.Wehrlé,

  T.Dalkara, P.P.DeLuca,

  Preparation and Characterization of bFGF and BSA Loaded Microspheres,

  J.Drug Del. Sci. Tech.15,371 (2005)

 

- D. H.Na, J. Faraj, Y.Capan, K.P. Leung, P.P. DeLuca

  Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque

  agent.Preformulation study

  J Control Release 107 ,122 (2005)

 

- Aktas Y, Yemisci M, Andrieux K, Gursoy RN, Alonso MJ, Fernandez-Megia E,

  Novoa-Carballal R, Quinoa E, Riguera R, Sargon MF, Celik HH, Demir AS, Hincal

  AA, Dalkara T, Capan Y, Couvreur P.

  Development and brain delivery of chitosan-PEG nanoparticles functionalized

  with the monoclonal antibody OX26.

  Bioconjug. Chem.  16,1503(2005)

 

M.Yemisci, İ.Vural, S. Bozdağ, M. Çetin, F. Söylemezoğlu, Y. Çapan, T. Dalkara,

  Treatment of Malignant Glioma with Mitoxantrone-Loaded PLGA Microspheres,

  Neurosurgery. 59 ,1296 (2006)

 

JA. Faraj , R. Dorati , A. Schoubben, D. Worthen, F. Selmin,Y. Capan, K. Leung, P

  P  DeLuca

  The Development of a Peptide Containing Chewing Gum as a Sustained 

  ReleaseAntiplaque Antimicrobial Delivery System.

  AAPSPharmSci.Tech. 8 (1), 26 (2007)

 

- Na DH, Faraj J, Capan Y, Leung KP, DeLuca PP.

  Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the

  oral cavity.

  Pharm Res 24, 1544-50 (2007)

 

Cetin, M., Aktas, Y., Vural, I., Capan, Y.;

Preparation and In Vitro Evaluation of bFGF-Loaded Chitosan Nanoparticles;        

  Drug Delivery; 14, 1–5; (2007)

 

- Cetin M, Youn YS, Capan Y, Lee KC.

 Preparation and Characterization of Salmon Calcitonin-biotin Conjugates.  

 AAPS PharmSciTech. 9(4), 1191-7; (2008)

 

Pinarbasli, O., Aktas, Y., Dalkara, T., Andrieux, K., Alonso, M.J., Fernandez-Megia, E.,R. Novoa-Carballal,

 R., Riguera, R., Couvreur, P., Capan, Y.

 Preparation and Evaluation of PBN-Encapsulated Chitosan and PEGylated Chitosan Nanoparticles

 Pharmazie, 64(7):436-9; (2009)

 

- A. Aktaş, B. Giray, Y. Çapan, D. Menemenlioğlu, M. Hayran, G. İkinci, İ. Vural,

Microbiological and clinical comparison of chlorhexidine buccoadhesive tablet and chlorhexidine

mouthrinse,

J. Drug Del. Sci. Tech., 19 (5) 353-357 2009

 

- Karatas H, Aktas Y, Gursoy-Ozdemir Y, Bodur E, Yemisci M, Caban S, Vural A, Pinarbasili O,

  Capan Y, Fernandez-Megia E, Novoa-Carballal R, Riguera R, Andrieux K, Couvreur P, Dalkara T,

A nano-medicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and

provides neuroprotection,

  J. Neuroscience 2009 Nov 4;29(44):13761-9

 

Journal Articles (Refereed)

Journal Articles (Not Refereed)

- N. Ünlü, Y. Çapan, N. Yuluğ

  Formulation Studies of the Wetting Solutions for Hard Contact Lenses I.

  Microbiyol. Bull., 15, 179 (1981)

 

- N. Ünlü, Y. Çapan, N. Yuluğ

  Formulation Studies of the Wetting Solutions for Hard Contact Lenses II.

  FABAD  J. Pharm. Sci., 7, 125 (1982)

 

-Y. Çapan

  Le Choix des Excipients en Compression Directe à l'Aide des Energies de

  Compression

  FABAD J. Pharm. Sci. , 9, 108 (1984)

 

- T. Eldem, Y. Çapan

  Formulation Studies on Sustained Release  Nitrofurantoin Tablets.

  Bull. Hacettepe University Faculty of Pharmacy  4, 9 (1984)

 

- Y. Çapan, A. A. Hıncal

  The Physics of Tablet Compression I.

   FABAD J. Pharm. Sci. 9, 93 (1984)

 

- Y. Çapan, A. A. Hıncal

   The Physics of Tablet Compression II.   The Strength of Tablets.

   FABAD J. Pharm. Sci., 11, 82 (1986)

 

-  S.Şenel, Y.Çapan, A.A.Hıncal

   Applications of Thermal Analysis in Pharmaceutics.

  FABAD J. Pharm. Sci., 17, 45 (1992)

 

-  Ş. Anlar, Y. Çapan, A. A. Hıncal

   Bioadhesive Controlled Release Systems I Fundamentals of Bioadhesion.

   FABAD J. Pharm. Sci., 17, 203 (1992)

 

-  Ş. Anlar, Y. Çapan, A. A. Hıncal

   Bioadhesive Controlled Release Systems II. Experimental Methods for Evaluation                       

   of  Bioadhesive Bond Strength of  Polymers with Mucus.

   FABAD J. Pharm. Sci., 17, 277 (1992)

 

- Y. Çapan

   Properties and Evaluation of Sustained Release Tablets.

   FABAD J. Pharm. Sci., 18, 27( 1993)

 

-  F.S. Farshi, Y. Çapan, A.A. Hıncal

   Topographical  Dissolution  Characterization  for  Sustained-Release  Furosemide      

   Tablets.

   Acta Pharmaceutica Turcica., 36, 118 (1994)

 

- Y.Çapan

   ISO 9000 Standards and GMP

   POSYON, 3, 12 (1994)

 

- Y. Çapan

   Quality Assurance and ISO 9000 in Pharmaceutical Industry.

   POSYON, 4, 44 (1995)

 

- Y. Çapan

   Novel Approaches in Pharmaceutical Dosage Forms

   Rapor, 8, 4 (1995)

 

- Y. Çapan

   Recent Pharmacopeial Controls Used for the Evaluation of Solid Dosage 

   Forms - I.

   POSYON, 5, 36 (1996)

 

-  F.S. Farshi, Y. Çapan, A.A. Hıncal,

   Bioavailability File: Furosemide

   FABAD J. Pharm. Sci., 21, 87 (1996)

 

- Y. Çapan

   Recent Pharmacopeial Controls Used for the Evaluation of Solid Dosage Forms - II

   POSYON, 5, 71 (1996)

 

- Y.Çapan

   Controlled-Release Oral Solid Dosage Forms, General Principles

   Posyon, 5, 117 (1996)

 

- Y. Yazıksız, Y. Çapan, A.A.Hıncal

   Buccal Adhesive Drug Delivery Systems

   FABAD J. Pharm. Sci., 22, 65 (1997)

 

- H.Selek, Y.Çapan, H.S.Kaş

  Starch Microspheres: Importance, Preparation and Applications

  FABAD J. Pharm. Sci., 24, 31 (1999)

 

-  İ. Yenice, S. Çalış, Y. Çapan

Quality Control of Conventional and Controlled-Release Carbamazepine Tablets Available

in Turkish Market

H.U. J.  Fac. Pharm., 20, 45 (2000)

 

 R. Elqidra, N. Ünlü, Y.Çapan, A.A. Hıncal

   Effect of Polymorphism on Carbamazepine Tablet Characteristics

 H.U. J.  Fac. Pharm., 21, 83 (2001)

 

 - S. Bozdağ, İ. Vural, Y. Çapan, T. Dalkara

   Application of Drug Carrier Systems for Brain Tumor Therapy

   FABAD J. Pharm. Sci., 27, 89 (2002)

 

-  M.Çetin , Y. Çapan

   bFGF ( Basic Fibroblast Growth Factor ) and a novel approach to its formulations

 H.U. J.  Fac. Pharm., 24, 107 (2004 )

 

- M.Cetin,Y.Capan

Brain Drug targeting

J.Fac.Pharm. Ankara,33,287(2004)

 

-  S. Bozdağ, Y. Çapan, İ. Vural. A.A.Hıncal

 Method Validation in Determination of Mitoxantrone by HPLC

 Acta Pharmaceutica Turcica.,46:43 ( 2004)

Book Chapters

-     S. Şenel, Y. Çapan and A. A. Hıncal

Factors Affecting the Formulation of Sustained Release Potassium Chloride Tablets

In: PHARMACEUTICAL TECHNOLOGY

      Controlled Drug Release Vol. 2 J. I. Wells and Rubinstein (Eds.)

      pp. 34-43, Ellis Harwood, New York, 1991 

 

-     Y. Çapan,

      Pharmaceutical Factors Affecting Bioavailability and Bioequivalance.

      In: BIOAVAILABILITY AND BIOEQUIVALANCE

      L. Öner, M. Şumnu, A.A.Hıncal (Eds.)

      Şafak Matbaası, Ankara, 1995.

 

-     S. Şenel, Y. Çapan, M.F. Sargon, D. Solpan, O. Güven, H.E. Boddé, A.A. Hıncal,

Enhancing Effect of Sodium Glycodeoxycholate on Diffusion Rate of Morphine 

      Sulfate Through Buccal Epithelium

      In: P. Couvreur, D.D. Duch(ne, I. Kalles, ( Eds),

      pp. 441- 445, MINUTES, Formulation of Poorly-Available Drugs for Oral  

      Administration,

      European Symposium, Editions de Santé Publishers, Paris, 1996. 

 

-     Y. Çapan

Kontrollü Salım Sistemlerinin Salım Mekanizmaları ve Kullanılış Yolları (Release 

      Mechanisms of  Controlled  Release Systems and Administrations Routes )                                       

      In: Kontrollü Salım Sistemleri (Controlled Release Systems)

      A. Gürsoy (Ed)

      pp.41-64, Elma Bilgisayar Basım ve Ambalaj San. Tic. Ltd. Şti, İstanbul, 2002.

 

-     Y. Çapan

      Mukozaya Yapışan Sistemler (Mucoadhesive Systems )

      In: Kontrollü Salım Sistemleri  (Controlled Release Systems)

      A. Gürsoy (Ed)

      pp.177-196, Elma Bilgisayar Basım ve Ambalaj San. Tic. Ltd. Şti, İstanbul, 2002.

 

-     Y. Çapan

Çözünürlük ve çözünme hızına etki eden faktörler (Solubility and factors effecting solubility rate)

      In: Farmasötik Teknoloji (Pharmaceutical Technology)

      A. Gürsoy (Ed.)

 pp. 85-96, Piksel Bilişim Matbaacılık Reklamcılık ve Filmcilik Hizmetleri Ltd. Şti., İstanbul, 2004.

 

-     Y. Çapan

      Biyoyararlanım (Bioavailability)

      In: Farmasötik Teknoloji (Pharmaceutical Technology)

      A. Gürsoy (Ed.)

pp.159-168, Piksel Bilişim Matbaacılık Reklamcılık ve Filmcilik Hizmetleri Ltd. Şti., İstanbul, 2004.

 

-     O. Pinarbasli, Y. Aktas, Y. Capan

      Development and Validation of an Analytical Method for The Determination          of PBN  from

     Chitosan Nanoparticles

      In: Advances in Chitin Science

      S.Senel, K.M. Varum, M.M. Sumnu, A.A. Hincal (Eds),

pp: 370-375, . Alp Ofset, Ankara, 2007