Mahir Yusuf Açan

About

Research

Articles:

• Acan, MY. (2021). Investigation of MEF2A Activation and Its Relationship with Pathways [LINK]
• Acan, MY. (2020). Turkey and Economic Development [LINK]
• Acan, MY. (2021). Lionfish [LINK]
• Acan, MY. (2019). Parkinson Disease [LINK]
• Acan, MY., (2020). Investigation of the effect of the MEF2A variant on myocardial infarction and coronary artery disease
• Acan, MY., (2022). Examination Of The Effects On Patients With Marginal Zone Lymphoma After BNT162B2 Administration
• Acan, MY., (2023). A Comparative Study of Machine Learning Algorithms for Parkinson's Disease Diagnosis
• Acan, MY., (2023). Clustering of P53 and CENPA Regulation in MCF10A Cells Using Gene Expression Profiles: Application of K-means Algorithm

Research Topics

• HTRA2: HTRA2 (also known as Omi or HtrA2) is a serine protease that is involved in the regulation of protein degradation and stress responses in cells. It is a member of the high temperature requirement A (HtrA) family of proteins, which are characterized by their ability to degrade misfolded proteins and promote their turnover. HTRA2 is activated by stress signals, such as oxidative stress, and it cleaves a number of target proteins, including components of the cytoskeleton, extracellular matrix, and signaling pathways. HTRA2 has been implicated in a variety of physiological processes, including cell migration, apoptosis, and inflammation. Dysregulation of HTRA2 has been linked to the development of diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders. Therefore, HTRA2 is a potential therapeutic target for the treatment of these conditions.
• AIMP2: AIMP2 (also known as p38gamma or ERP44) is a member of the p38 mitogen-activated protein kinase (MAPK) family of proteins, which play a role in signaling pathways that regulate inflammation and stress responses in cells. AIMP2 is activated by stress signals, such as oxidative stress and UV radiation, and it phosphorylates downstream target proteins, leading to the activation of transcription factors and the expression of genes involved in stress response and inflammation. AIMP2 is expressed in a variety of tissues, including the liver, kidney, and heart, and it has been implicated in the regulation of various physiological processes, such as cell proliferation, differentiation, and apoptosis. Dysregulation of AIMP2 has been linked to the development of diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders. Therefore, AIMP2 is a potential therapeutic target for the treatment of these conditions.
• Sirtuin Gene: Sirtuins are a class of enzymes that play a role in regulating gene expression, cell aging, and metabolism. They are a type of protein deacetylase that remove acetyl groups from lysine residues on histone proteins and other proteins, leading to the modulation of gene expression. There are seven known sirtuins in humans (SIRT1-7), which have different tissue distribution and substrate specificities. SIRT1, for example, is expressed in a variety of tissues and is involved in the regulation of metabolism, stress response, and aging. SIRT6, on the other hand, is mainly expressed in the liver and is involved in DNA repair and glucose metabolism. Sirtuins are activated by the presence of the coenzyme NAD+, and they require NAD+ as a substrate to remove acetyl groups. The activity of sirtuins is regulated by the levels of NAD+ in the cell. For example, during periods of caloric restriction, the levels of NAD+ increase, leading to the activation of sirtuins and the modulation of gene expression. Dysregulation of sirtuin function has been linked to a number of diseases, including cancer, diabetes, and neurodegenerative disorders. Therefore, sirtuins are of great interest to researchers and may represent potential therapeutic targets for the treatment of these conditions.
• Epigenomic Studies: Epigenomic studies are a type of research that investigates the role of epigenetic modifications in gene expression and the development of diseases. Epigenetic modifications are changes to the genome that do not involve changes to the DNA sequence itself, but rather involve the addition or removal of chemical modifications to the DNA molecule or to the proteins with which it interacts. These modifications can alter the activity of genes without changing their underlying DNA sequence. Some examples of epigenetic modifications include methylation of cytosine bases in DNA, acetylation and methylation of histone proteins, and the addition of small RNA molecules. These modifications can be reversible and can be influenced by environmental factors such as diet, stress, and toxins. Epigenomic studies aim to understand how these epigenetic modifications are regulated and how they affect gene expression and cellular function. These studies often involve the use of high-throughput technologies such as DNA sequencing and microarray analysis to measure the levels of various epigenetic modifications in different tissues or cell types. The findings from epigenomic studies have important implications for our understanding of gene regulation and the development of diseases such as cancer, cardiovascular disease, and neurological disorders. They may also provide insight into potential therapeutic targets and the development of new treatments for these conditions.
• NAD Metabolism: Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It plays a crucial role in energy metabolism as a carrier of electrons and a substrate for a number of enzymes involved in redox reactions. NAD is a dinucleotide, meaning that it consists of two nucleotides joined together. The nucleotides are adenine and nicotinamide, and the molecule is composed of an adenine nucleotide covalently linked to a nicotinamide nucleotide via a pyrophosphate bridge. There are two forms of NAD: NAD+ and NADH. NAD+ is the oxidized form of the molecule, while NADH is the reduced form. The conversion between the two forms is reversible and is coupled to the transfer of electrons. In metabolism, NAD+ acts as a hydrogen acceptor, accepting two electrons and a proton to become NADH. The transfer of these electrons from one molecule to another is an important source of energy for cells. NADH then donates these electrons to the electron transport chain, a series of proteins in the mitochondria that generate ATP, the primary energy currency of cells. NAD+ is also a substrate for a number of enzymes that use it to transfer electrons in redox reactions. One example of such an enzyme is sirtuin, a class of enzymes that play a role in regulating gene expression, cell aging, and metabolism. Dysregulation of NAD metabolism has been linked to a number of diseases, including diabetes, cancer, and neurodegenerative disorders. Therefore, understanding NAD metabolism and its role in cellular processes is of great interest to researchers and may lead to the development of new therapies for these diseases.
• Ampk Pathway: AMP-activated protein kinase (AMPK) is a protein kinase that plays a key role in regulating cellular energy homeostasis in eukaryotic cells. It is activated by an increase in the AMP:ATP ratio, which occurs under conditions of cellular stress, such as low glucose or oxygen levels, or high energy demand. Once activated, AMPK phosphorylates a number of downstream target proteins that help to restore energy balance in the cell. The AMPK pathway is activated by a number of signaling molecules, including LKB1, Ca2+, and AMP. Activation of AMPK leads to the phosphorylation of downstream target proteins, such as acetyl-CoA carboxylase (ACC) and p70 ribosomal S6 kinase (S6K). Phosphorylation of ACC leads to decreased fatty acid synthesis and increased fatty acid oxidation, while phosphorylation of S6K leads to decreased protein synthesis and increased glucose uptake. AMPK is involved in a wide range of physiological processes, including glucose and lipid metabolism, insulin signaling, cell growth and differentiation, and stress response. Dysregulation of the AMPK pathway has been implicated in the development of various diseases, including diabetes, obesity, and cancer. Therefore, AMPK is a potential therapeutic target for the treatment of these conditions.

Journal

• ACAN, MY. (2018). 'What if we've misunderstood our place in the universe',BIOFEN.

Software

Data Science

If you wish to see the codes of this projects, you can access the public repository here.

Blog

LinkedIn:

• Lionfish that are as dangerous as they look beautiful
• Parkinson's Disease
• Uncontrolled Antibiotic Use in Infancy Triggers Chronic Diseases
• Graphene-based memory resistors could be used to build brain-based computers
• Dutch Scientists Discover New Organ in Human Throat
• Biologists Identify a Bird with One Male Side and One Female Side
• A Human-like Consciousness Discovered in Crows
• Time Travel Paradox May Have Been Solved
• Planet Pi Discovered

You can reach my blog-tye articles on this page. I have only 9 articles on this page and you can find the rest on my LinkedIn page.