Research Projects
I. International Projects :
“Preparation and Evaluation of Biodegradable Microparticles for Oral Controlled Drug Delivery”
International Project (Following the Treaty Between TÜBİTAK and Ministry of Science of Macedonia) Hacettepe University and Sv. Kiril & Metodij University of Macedonia 2004-
Project Coordinator : Prof.Dr. Sema ÇALIŞ (Turkey)
Project Coordinator : Prof. Dr. Katerina GORACINOVA (Macedonia)
“Development and Evaluation of Biodegradable Drug Delivery Systems for Anticancer Therapy”
International Project( Following the Treaty Between TÜBİTAK and Ministry of Science of Macedionia) Hacettepe University and Sv. Kiril & Metodij University of Macedonia 2000-2002.
Project Coordinator : Prof.Dr. Sema ÇALIŞ (Turkey)
Project Coordinator : Assoc. Prof. Emilija KUMBARADZI (Macedonia)
“Development and Evaluation of Biodegradable Microspheres for Peptide Delivery”
Medidom Research Project
University of Kentucky - USA (1991-1993)
Project Coordinator : Prof. Dr. Patrick P. DELUCA
Reseacher : Assoc.Prof. Sema ÇALIŞ
a) Development and Evaluation of Biodegradable Microspheres for Peptide Delivery (Third Annual Report) R. Jeyanthi, S. Çalış, B.C. Thanoo, K.W. Burton, A.G. Hausberger, R.C. Mehta and P.P.DeLuca, March 30,1992.
b) Development and Evaluation of Biodegradable Microspheres for Peptide Delivery (June 1992, Quaterly Report) R. Jeyanthi, S. Çalış, B.C. Thanoo, K.W. Burton, R.C. Mehta and P.P. DeLuca, July 9, 1992
c) Development and Evaluation of Biodegradable Microspheres for Peptide Delivery (Quaterly Report) R. Jeyanthi, K.W. Burton S. Çalış, B.C. Thanoo, R.C. Mehta and P.P. DeLuca, October 17, 1992.
d) Development and Evaluation of Biodegradable Microspheres for Peptide Delivery
Report on:
I Storage Stability of Lyophilized Product
II Effect of 60 Co-Gamma Irradiation on sCT Microspheres
III Scale-up and Optimization of Microsphere Preparation Process R.Jeyanthi, B.C.
Thanoo, S. Çalış, K.W. Burton, R.C. Mehta and P.P. DeLuca, January 28, 1993.
e) Development and Evaluation of Biodegradable Microspheres for Peptide Delivery
Report on:
I Scale-up of Microsphere Preparation Process
II Stability of sCT Microspheres
III Bioavailability of Scaled-up Microspheres R. Jeyanthi, B.C. Thanoo, S. Çalış,
K.W. Burton, R.C. Mehta and P.P. DeLuca April 29, 1993.
II. National Projects :
Industry Supported Project: NOVARTIS Pharmaceutical Technology Research Supports
“In Vitro and In Vivo Evaluation of Topic and/or Injectable Gel Type Formulations of 5-Fluorouracil Used for the Treatment of Human Papilloma Virus (HPV) Originated Genital Diseases”
Project Coordinator : Erem BİLENSOY, Ph.D.
Reseachers : Prof. Dr. Sema Çalış,
A. Lale Doğan, M.D.,
Perran Moröy, M.D.
Industry Supported Project : ECZACIBAŞI Scientific Research and Award Fund
“Development and Evaluation of Implantable Formulations of Antibiotic Incorporated Biodegradable Microspheres for Treatment of Osteomyelitis in Orthopoedical Applications”
Project Coordinator : Assoc. Prof. Sema ÇALIŞ
Reseachers : Assoc. Prof. Bülent Atilla, Prof. Dr. Mazhar Tokgözoğlu,
Prof. Dr. Mümtaz Alparslan, Prof. Dr. Süheyla Kaş,
Prof. Dr. A. Atilla Hıncal, Assist. Prof. Meral Özalp,
İrem Yenice.
Hacettepe University Research Fund Projects
“Antibacterial activity of triclosan coated graft on hernia graft infection model"
Proje No : 2007
Project Coordinator : Prof. Dr. Volkan Kaynaroğlu
Reseachers : Dr. Attila Çakmak, Assist.
Prof. Dr. Erem Bilensoy,
Pharm. Yasemin Çırpanlı, M.Sc. ,
Assist. Prof. Dr. Zeynep Sarıbaş,
Prof. Dr. Sema Çalış,
Prof. Dr. Gülşen Hasçelik,
Assoc. Prof. Dr. Kaya Yorgancı
“Implantation of Antibiotic Impregnated Allografts and Biopolymeric Microparticles to Infected Bone Defects and Determination of Their Efficiency”
Proje No : 0201301003
Project Coordinator : Assoc. Prof. Sema ÇALIŞ
Reseachers : Assoc. Prof. Bülent Atilla,
Prof. Dr. A. Atilla Hıncal,
Assist. Prof. Meral Özalp,
Pharm. Burcu Sayın,
Salih Marangoz, M.D.
“Biodegradable and Controlled-Release Microparticulate Drug Delivery Systems”
Proje No : 02.G.121
Project Coordinator : Prof.Dr. Sema ÇALIŞ
Researchers : Pharm. Burcu Sayın,
Pharm. Sibel Şamdancıoğlu,
Pharm. Fatma Laleci
“Stability Evaluation in the Formulation of Drug Delivery Systems: Formulation and Stability Studies of Microspheres Containing Retinoic Acid”
Proje No :
Project Coordinator : Prof. Dr. Nurşen Ünlü, Prof. Dr. Sema ÇALIŞ
Reseachers : Yasemin Çırpanlı, M.Sc.,
Pelin Aksungur, M.Sc.
“Studies on Controlled-Release Formulations of Naproxen and In Vitro/In Vivo Evaluation”
Proje No : 97.02.301.003, 1998.
Project Coordinator : Assoc. Prof. Sema ÇALIŞ
Reseachers : Prof. Dr. Süheyla Kaş,
Prof. Dr. A.Atilla Hıncal,
Prof. Dr. Meral Ercan,
Sibel Bozdağ, M.Sc.
TÜBİTAK Research Projects
“The Development of a Novel Drug Delivery System for the Treatment of Cancer – The Identification of Ferritin-Doxorubicin Complex and the In Vitro Investigation of Cytotoxic Effects”
Project No :
Project Coordinator : Dr. Mehmet Akif Kılıç,
Reseachers : Dr. Aysun Özkan,
Res. Ass. Ayşegül Ayhan,
Prof. Dr. Sema ÇALIŞ
“Development of Oral Multiple Emulsion Formulation of Salmon Calcitonin forTreatment of Osteoporosis”
Project No : SBAG 1773, 1998
Project Coordinator : Assoc. Prof. Sema ÇALIŞ
Reseachers : Prof. Filiz Öner,
Prof. Dr. Süheyla Kaş,
Prof. Dr. A.Atilla Hıncal,
Pharm. Tolga Doğru.
“Investigation of Stability of Solid Dosage Forms in Accelarated Conditions”
Project No : SBAG-AYD-38. 1995-1996.
Project Coordinator : Prof.Dr. Murat Şumnu
Reseachers : Assoc. Prof. Sema Çalış,
Pharm. Sibel Bozdağ