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COURSE INFO
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Schedule:
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Classes: Mondays 13:00
- 15:50 / D2
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Objectives:
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To instill technical competence in science of biochemistry and enzyme engineering. To develop problem solving skills on enzyme kinetics and enzymatic processes. To develop an ability to design theoretically the experiments about enzymatic reaction kinetics, and analyze and interpret given data. To instill an ability to use the techniques
and skills necessary for enzyme engineering practice. To instill an ability to engage in life - long learning.
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Learning
outcomes:
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1.
An ability to design theoretically
the experiments about enzyme kinetics as well as to analyze and interpret given data,
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An ability to identify, formulate, and solve problems on biochemistry, enzyme kinetics, enzymatic processes for industrial applications,
3.
Recognition of the needfor, and an ability to engage in life-long learning,
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An ability to use the
techniques and skills necessary for industrial applications of enzymes.
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Course
Content:
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Definition
and content of biotechnology, life chemicals,
mechanisms of enzyme action and detailed enzyme kinetics, factors affecting enzyme activity, enzyme immobilization techniques, production and purification of enzymes, use of free and immobilized enzymes in industry.
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Grading:
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5 % Assignments,
5 % Project, 5 % Presentation, 35 % Midterm, 50 %
Final Exam
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References:
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J. Bailey
and D. Ollis , 'Biochemical Engineering
Fundamentals', 2nd ed., McGraw-Hill Book Company N.Y.(1986).
M.L. Shuler,
F.Kargı, "Bioprocess
Engineering", Prentice
Hall, New Jersey (1992).
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Weeks
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Topics
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Week 1
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Introduction: Introductory remarks, Biotechnology and Biochemical Engineer,
Development of Biotechnology
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Week 2
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The Basics
of Biology: Microbial Diversity, Viruses, Protist Kingdom, Procaryotes, Archaebacteria, Eucaryotes
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Week 3
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Lipids, Fats, Steroids, Nucleic Acids, DNA, RNA
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Week 4
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Cell Nutrients,
Macronutrients, Micronutrients,
Growth Media
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Week 5
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The enzymes, Introduction, How enzymes work
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Week 6
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Enzymes kinetics, Introduction, Mechanistic models for simple enzyme kinetics, The rapid equilibrium
assumption, The quasi - steady - state asssumption
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Week 7
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Enzyme kinetics, free and immobilized enzyme systems, enzyme inhibition kinetics: competitive, noncompetitive, uncompetitive,
noncompetitive-mixed type
inhibition.
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Week 8
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Large scale production of enzymes, enzyme utilization in medicine ad industry
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Week 9
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Midterm
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Week 10
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Boundary - layer flow and turbulence, Flow past immersed
objects and packed and fluidized beds, Project Discussions
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Week 11
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Industrial enzymes and applications
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Week 12
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Industrial enzymes and applications
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Week 13
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Project Submission
and Presentations
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Week 14
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Project Presentations
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Week 15
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Preparation to final exam
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Week 16
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Final exam
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